An efficient copper-catalyzed synthesis of anilines by employing aqueous ammonia.
نویسندگان
چکیده
Under the catalysis of CuI/2-carboxylic acid-quinoline-N-oxide, the cross coupling reactions between aryl iodides or bromides and aqueous ammonia proceed very well to afford N-unprotected aniline derivatives in excellent yields. This inexpensive catalytic system shows great functional group tolerance and excellent reaction selectivity.
منابع مشابه
Efficient copper-catalyzed coupling of aryl chlorides, bromides and iodides with aqueous ammonia.
The copper(I)-catalyzed synthesis of a range of primary anilines from electron-rich and electron-deficient aryl halides including aryl chlorides has been achieved with aqueous ammonia, avoiding the need for inert atmosphere, expensive catalysts and ligands, anhydrous solvents, and additional base or other additives.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 24 شماره
صفحات -
تاریخ انتشار 2011